Cells Proliferation of Memory Phenotype CD8 T CD40 Ligation In Vivo Induces Bystander
نویسندگان
چکیده
منابع مشابه
Bystander Activation and Anti-Tumor Effects of CD8+ T Cells Following Interleukin-2 Based Immunotherapy Is Independent of CD4+ T Cell Help
We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells displaying a CD25(-)NKG2D(+) phenotype in a cytokine dependent manner, which were responsible for the anti-tumor effects. While much attention has foc...
متن کاملT Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation
Cytokine driven or "bystander" proliferation of T cells occurs in vivo independently of major histocompatibility complex-T cell receptor interactions. This process may be important for supporting T cell homeostasis and facilitating T cell responses to microbial antigens, and may involve the cytokine interleukin (IL)-15. In this study, we find that IL-15Ralpha-deficient (IL-15Ralpha(-/-)) mice f...
متن کاملBystander memory CD8 T cell proliferation after anti-CD40/IL-2 treatment is independent of CD4 T cells
Systemic cancer immunotherapy combining agonistic antiCD40 and interleukin 2 results in synergistic anti-tumor effects with marked antigen independent expansion of bystander memory CD8 T cells displaying anti-tumor abilities. Our lab has previously shown that this expansion coincides with a loss of peripheral CD4 T cells due to activation induced cell death. While much research to date has focu...
متن کاملThe development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40.
The immunologic requirements for generating long-lived protective CD8 T cell memory remain unclear. Memory CD8 populations generated in the absence of CD4 Th cells reportedly have functional defects, and at least a subset of CD8 T cells transiently express CD40 after activation, suggesting that direct CD4-CD8 T cell interactions through CD40 may influence the magnitude and functional quality of...
متن کاملBone marrow dendritic cells deficient for CD40 and IL-23p19 are tolerogenic in vitro
Objective(s): In addition to pro-inflammatory role, dendritic cells (DCs) can also be anti-inflammatory when they acquire tolerogenic phenotype. In this study we tested the role of CD40 and IL-23p19 in antigen presenting function of bone marrow-derived DCs (BMDCs) by comparing BMDCs derived from CD40 knockout (CD40KO-DCs) and IL-23p19 (IL-23p19KO-DCs) knockout mice wit...
متن کامل